SYSTEM ANALYSIS IN PROBLEMS OF THEORETICAL ONCOLOGY 

Gel'fandbeyn Yakov Aronovich, Doctor of engineering sciences, professor, University of Halifax (Canada) (Dalhousie University, 6299 South street, Halifax, NS B3H 3J5, Canada), honored inventor of Atvian SSR, doctor of engineering sciences (Latvia), full member of the New York Academy of Sciences, senior staff scientist, American Institute of Electrical and Electronics Engineers (IEEE), member of the Federation of American Scientists (FAS), American Geographical society (AGS), yakov.gelfandbein@sympatico.ca
Gel'fandbeyn Vladimir Yakovlevich, Doctor of physical and mathematical sciences, senior staff scientist, Stanford University (Stanford University 450 Serra Mall Stenford, CA 94305–2004), Gold Medalist of PROTEUS Biomedical (USA), yakov.gelfandbein@sympatico.ca
Levin Vitaliy Il'ich, Honored scientist of Russia, doctor of engineering sciences, professor, sub-department of mathematics, Penza State Technological University (1a Baydukova lane, Penza, Russia), vilevin@mail.ru

616–006.04:51–76 

Background. Nowadays people are under a great threat of oncological diseases. The “cancer” diagnosis sounds like a death sentence. Every year it appears to be the cause of death of millions of people. Many of them could have been saved, if there had been a methodology of early detection of the disease. Such methods should be based on a substantial theory of occurrence and development of malignant tumors.
Materials and methods. The object of research is cell sets of the human organism in the process of development, that is associated with possible occurrence of a malignant tumor. The research method was the use of the general theory of systems. Preliminarily the authors checked the correspondence of the human organism homeostasis processes to all postulates of the stated theory.
Results. It is established that in the human organism there exist two mechanisms of homeostasis remaining in antagonistic contradiction between each other. The first one is homeostasis itself, devoted to stabilization of cell growth at the limited level. The second one is antihomeostasis, devoted to elimination of homeostasis by stabilization of the process of unlimited growth of cells in the organism.
Conclusions. It is shown that occurrence and development of malignant tumors is a natural technological process of cell sets transformation in the human organism. The cell situation of malignant tumor development forms a system of cell growth stabilization, that is devoted to elimination of homeostasis and organization of antihomeostasis, which is harmful for the organism. The systems of homeostasis and antihomeostasis have the features of systems. It allows to use the general theory of systems for oncological processes simulation. 

cell set, cell interaction, cell growth, homeostasis, system, malignant tumor, malignization. 

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